Terpendole
WebNov 7, 2024 · Diterpenes are one of the classes of natural products with about 7000 structures. The basic skeleton of diterpene contains 20 carbon atoms. Microbes contain … WebJan 2, 2015 · Terpendole E (1), originally isolated from the fungus Albophoma yamanashiensis (syn. Chaunopycnis alba) as a week ACAT (acyl-CoA: cholesterol acyltransferase) inhibitor, 1,) has been gaining increasing attention from cancer researchers since its rediscovery by Osada and co-workers as the first natural inhibitor of the mitotic …
Terpendole
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WebTerpendole I is a fungal metabolite that has been found in A. yamanashiensis.1 It is a weak inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 145 μM) and is active against the bacteria B. cereus and B. subtilis (MICs = 100 μg/ml for both) but not S. aureus, P. aeruginosa, or K. pneumoniae (MICs = >200 μg/ml for all) or the fungus C. … WebFeb 1, 2003 · Terpendole E Is a Selective Inhibitor of Eg5 Rather Than an ACAT Inhibitor. Since terpendole derivatives were isolated as ACAT inhibitors, we next compared the …
WebTerpendole C. Cat. No.: HY-N10224. Data Sheet Handling Instructions. Terpendole C, produced by Albophoma yamanashiensis, shows potent inhibitory activity against acyl-CoA: cholesterol acyltransferase ( ACAT ). For research use only. WebAbstract. To reveal the mechanism of mitosis, the development of M phase-specific inhibitors is an important strategy. We have been screening microbial products to find specific M phase inhibitors that do not directly target tubulins, and rediscovered terpendole E (TerE) as a novel Eg5 inhibitor. TerE did not affect microtubule integrity in ...
Terpendole E is the first natural product inhibitor of kinesin Eg5. Because terpendole E production is unstable, we isolated and analyzed the terpendole E biosynthetic gene cluster, which consists of seven genes encoding three P450 monooxygenases (TerP, TerQ, and TerK), an FAD-dependent monooxygenase (TerM), a terpene cyclase (TerB), and two prenyltransferases (TerC and TerF). WebTetrindole. Tetrindole was a drug candidate that functions by reversibly inhibiting monoamine oxidase A; it was first synthesized in Moscow in the early 1990s. [1] …
WebTerpendole E is first natural product found to inhibit mitotic kinesin Eg5, but its inhibitory mechanism remains to be revealed. Here, we report the effects of terpendole E and …
WebTerpendole E is a mitotic kinesin Eg5 (Kinesin-5) inhibitor isolated from Albophoma yamanashiensis that inhibits both motor and microtubule stimulated ATPase activities of … the war horse puppetWebDec 15, 2016 · Isolation of a terpendole E analog with stronger kinesin Eg5 inhibitory activity: Overproduction of bioactive compounds may cause production of shunt metabolites with improved bioactivity. Indeed, a new terpendole E analog was isolated from a terP-knockout strain that stably overproduced terpendole E. 11 After prolonged culture, ... the war horse symposiumhttp://www.fluoroprobe.com/archives/tag/ccd the war hound and the world\u0027s painWebTerpendole M (1), a novel indole-diterpenoid, was isolated from perennial ryegrass (Lolium perenne) infected with the endophytic fungus Neotyphodium lolii. It was identified as 14alpha-hydroxyterpendole C by NMR and mass spectral techniques. The known indole-diterpenoids paspaline (3) and 13-desoxypaxilline (4) were also isolated from perennial ... the war horse buckshawWebThe application of the Nazarov photocyclization as a mild and efficient method for access to the basic core of novel indoloditerpenoid derivatives is reported. The detailed synthesis of these new analogues of terpendole E, as well as their evaluation as potential inhibitors of KSP, is described. the war houseWebFirstly, consecutive rings, including an indole or indoline, maintain the cornerstone for SOAT inhibitory activity because the opened ring A leads to the loss of activity in terpendole N. Secondly, the comparison among terpendole D, J, L, O and P; voluhemins A and B; and NK12838 shows that the presence of an isoprenyl-derived moiety at the C-20 ... the war hound and the world\\u0027s painWebTipindole definition: A serotonin antagonist . the war house sittingbourne