Hif1a protein
WebHypoxia-inducible factor 1 (HIF1) is a heterodimeric transcription factor that plays a critical role in the cellular response to hypoxia (1). The HIF1 complex consists of two subunits, HIF-1α and HIF-1β, which are basic helix-loop … Hypoxia-inducible factor 1-alpha, also known as HIF-1-alpha, is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) that is encoded by the HIF1A gene. The Nobel Prize in Physiology or Medicine 2024 was awarded for the discovery of HIF. HIF1A is a basic helix-loop-helix PAS … Ver mais HIF1 is a heterodimeric basic helix-loop-helix structure that is composed of HIF1A, the alpha subunit (this protein), and the aryl hydrocarbon receptor nuclear translocator (Arnt), the beta subunit. HIF1A contains a … Ver mais The transcription factor HIF-1 plays an important role in cellular response to systemic oxygen levels in mammals. HIF1A activity is … Ver mais HIF1A is overexpressed in many human cancers. HIF1A overexpression is heavily implicated in promoting tumor growth and metastasis through its role in initiating angiogenesis and regulating cellular metabolism to overcome hypoxia. Hypoxia promotes apoptosis … Ver mais • Hypoxia inducible factors Ver mais The human HIF1A gene encodes for the alpha subunit, HIF1A of the transcription factor hypoxia-inducible factor (HIF1). Its protein expression level can be measured by antibodies against HIF-1-alpha through various biological detection methods including western … Ver mais HIF1A abundance (and its subsequent activity) is regulated transcriptionally in an NF-κB-dependent manner. In addition, the coordinated activity … Ver mais HIF1A has been shown to interact with: • ARNTL, • ARNT, • CREBB, • EP300, • HIF1AN, Ver mais
Hif1a protein
Did you know?
WebHIF1A. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. … Web3 de mar. de 2024 · HIF1A protein is well known to have less stability under normoxic conditions. Whereas under hypoxic conditions, HIF1A protein is stabilized due to inhibition of prolyl hydroxylase activity 2 , 38 .
Web25 de mar. de 2024 · We further transduced adenoviral vectors of Cre recombinase or GFP into primary chondrocytes derived from Hif1a fl/fl mice. Hif1a protein level in Cre-transduced cells was decreased to 17.7% of ... Web8 de mai. de 2015 · A highly integrated quaternary architecture is shared by HIF-2α-ARNT and HIF-1α-ARNT, wherein ARNT spirals around the outside of each HIF-α …
WebIldus I. Ahmetov, Olga N. Fedotovskaya, in Advances in Clinical Chemistry, 2015 2.14 HIF1A Pro582 Allele. Hypoxia-inducible factor-1α (HIF-1α; encoded by HIF1A; location: 14q23.2) is a transcription factor regulating several genes in response to hypoxic stimuli.HIF-1α mRNA and protein levels were found to be constitutively higher in the … Web8 de mai. de 2015 · A highly integrated quaternary architecture is shared by HIF-2α-ARNT and HIF-1α-ARNT, wherein ARNT spirals around the outside of each HIF-α subunit. Five distinct pockets are observed that permit small-molecule binding, including PAS domain encapsulated sites and an interfacial cavity formed through subunit heterodimerization.
WebHypoxia-inducible factor 1 (HIF-1) is a basic helix-loop-helix protein that activates transcription of hypoxia-inducible genes, including those encoding: erythropoietin, …
WebInteracts with RORA (via the DNA binding domain); the interaction enhances HIF1A transcription under hypoxia through increasing protein stability (PubMed:18658046). … byer fountain motor innWeb保存条件: HIF-1alpha/HIF1A Mouse Monoclonal Antibody -20ºC保存,需避免反复冻融。Western一抗稀释液-20℃或4℃保存,一年有效,Western一抗稀释液优先推荐4℃保存,长期不使用可以考虑-20℃保存,但冻融可能会导致出现轻微的浑浊和少量不溶物。 byeri ap art historyWebhif1a Hypoxia-inducible factor 1-alpha; Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the … bye rite furnitureWeb1 de fev. de 2004 · Hypoxia-inducible factor (HIF-1) is an oxygen-dependent transcriptional activator, which plays crucial roles in the angiogenesis of tumors and mammalian development. HIF-1 consists of a ... byer i toscanaWebHIF1A is part of cluster 20 Connective tissue cells - ECM organization with confidence i Confidence is the fraction of times a gene was assigned to the cluster in repeated … byerlee frictionWebFAQs for HIF-1 alpha Full Length Recombinant Protein (H00003091-P01). (Showing 1 - 10 of 12 FAQs). Why is there a difference between the theoretical MW for HIF1A and the observed MW for HIF-1 alpha? HIF1A, like many other … byer i walesWeb21 de mar. de 2024 · HIF1A (Hypoxia Inducible Factor 1 Subunit Alpha) is a Protein Coding gene. Diseases associated with HIF1A include Retinal Ischemia and Enchondromatosis, … bye rite trailer and fabrication