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Fth1 cell

WebOct 5, 2015 · Through analysis of the NCOA4-FTH1 interaction, we demonstrate that direct association via a key surface arginine in FTH1 and a C-terminal element in NCOA4 is required for delivery of ferritin to the lysosome via autophagosomes. Moreover, NCOA4 abundance is under dual control via autophagy and the ubiquitin proteasome system.

Ferritin heavy chain (FTH1) exerts significant antigrowth effects in ...

This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major … See more Ferritin heavy chain is a ferroxidase enzyme that in humans is encoded by the FTH1 gene. FTH1 gene is located on chromosome 11, and its mutation causes Hemochromatosis type 5. See more FTH1 has been shown to interact with ferritin light chain. See more • Percy ME, Wong S, Bauer S, Liaghati-Nasseri N, Perry MD, Chauthaiwale VM, Dhar M, Joshi JG (January 1998). "Iron metabolism and human ferritin heavy chain cDNA from … See more • Ferritin See more WebNov 28, 2024 · FTH1 Pseudogenes in Cancer and Cell Metabolism Cells. 2024 Nov 28 ... their role in controlling gene expression in normal and transformed cells has recently … god\u0027s plan of salvation church of christ https://impactempireacademy.com

Value of Ferritin Heavy Chain (FTH1) Expression in

WebImmunohistochemical analysis of paraffin-embedded HeLa cell pellet (left, high-expressing) or HL-60 cell pellet (right, low-expressing) using FTH1 (D1D4) Rabbit mAb. Western blot analysis of extracts from Huh7 and Hep G2 cells … WebDec 29, 2024 · Background Ferroptosis is a newly identified type of programmed cell death, which preferentially targets iron-rich cancer cells such as hepatocellular carcinoma … WebHuman cell lines. GENERAL INFORMATIONi. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions … god\u0027s plan of salvation images

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Category:Immune cell - FTH1 - The Human Protein Atlas

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Fth1 cell

FTH1 (D1D4) Rabbit mAb Cell Signaling Technology

WebDec 21, 2024 · Within expectation, a simultaneous degradation of NCOA4 and FTH1 was observed in cisplatin-treated BUMPT cells, which was partially restored by myo-inositol treatment (Figure 3O, lanes 1 and 2). All in all, these in vitro data indicated that myo -inositol down-regulates the expression profile of NOX4 to decelerate ferroptosis in cisplatin ... WebApr 11, 2024 · Esculetin was only proven to induce ferritinophagy in liver cancer cells via the NCOA4/LC3II/FTH1 pathway, but it is uncertain whether esculetin promotes ferritinophagy via other pathways or if it inhibits other cancers. Future experiments should investigate various cancers and pathways to better study esculetin’s antitumor …

Fth1 cell

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WebNov 23, 2024 · The cell migration by wound healing experiments did not show an apparent stable difference between FTH1-OE cells and vector control cells (Fig. S2). However, a quantitative live cell imaging system of both Caco-2 and SW480 cells showed that cells proliferated faster in the FTH1-OE group (Fig. 4b). In addition, EdU assays suggested … WebApr 3, 2024 · To further examine whether iron overload is caused by ferritinophagy, we assessed the effect of Sch B on the expression of FTH1 in cultured LX2 cells. The protein expression of FTH1 was increased by Sch B (Figure 4(e)). Additionally, Sch B promoted the binding of NCOA4 to FTH1 in vitro (Figure 4(f)). Collectively, these data suggested that …

WebFeb 1, 2024 · This identified four genes as significant: FTH1, RCC2, ABHD17B, and IRAK1. Through survival analysis, FTH1 was identified as a key gene associated with AML prognosis. We verified the proliferative and regulatory effects of ferroptosis on MOLM-13 and THP-1 cells using Liproxstatin-1 and Erastin respectively by CCK-8 and flow … WebSep 22, 2024 · The observation that FTH1 expression increases in response to chemotherapy raised the question of whether inhibition of FTH1 can render tumor cells more resistant to chemotherapy. To address this question, cell growth was examined in FTH1-silenced MCF-7 cells treated with increasing concentrations of DFO, vitamin C, 5 …

WebMay 12, 2024 · Cells were induced to undergo malignant transformation via indirect coculture with C6 glioma cells, and these transformed cells were named MTMSCs-PEG3-FTH1. Western blot analysis of FTH1 expression, Prussian blue staining and transmission electron microscopy (TEM) to detect intracellular iron, and MRI to detect signal changes … WebHowever, FTH1-overexpression-related cytotoxicity is required to be explored. METHODS: By using the Tet-Off system, FTH1 overexpression was semi-quantitativiely and …

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WebOct 7, 2024 · Ferroptosis is a form of regulated cell death that is characterized by iron-dependent oxidative damage and subsequent plasma membrane ruptures and the release of damage-associated molecular … book of matthews printable lessonsWebFTH1. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Official gene symbol, which is typically a short form of the gene name, according to HGNC. Full gene name according to HGNC. god\u0027s plans for me are goodWebDec 2, 2024 · In general, ferroptosis is a form of inflammatory cell death associated with the release of DAMPs (e.g., high mobility group box 1 (HMGB1) and DNA) or lipid oxidation products (e.g., 4HNE, oxPLs ... god\u0027s plans for my lifeWebHowever, FTH1-overexpression-related cytotoxicity is required to be explored. METHODS: By using the Tet-Off system, FTH1 overexpression was semi-quantitativiely and dynamicly regulated by doxycycline in a NPC cell line. Effects of FTH1 overexpression on the proliferation, cytotoxicity, apoptosis and migration of NPC cells were investigated in ... god\u0027s plan song downloadWebSep 9, 2024 · The link between FTH1 and LDs was further confirmed by the reduction of LD accumulation in FTH1-silenced cells. Moreover, FTH1 downregulation associated with the downregulation of transferrin receptor that mediates extracellular iron uptake and the upregulation of ferroportin, responsible for iron release, indicating that most likely iron ... book of matthews in the bibleWebApr 20, 2024 · Up to now, FTH1 is generally considered to have antioxidant properties that could protect cells from reactive oxygen species (ROS) due to its ferroxidase activity which could catalyse the conversion of Fe 2+ into Fe 3+. 17, 20 Meanwhile, NF‐κB‐mediated FTH1 upregulation is thought to protect cells from apoptosis. 35, 40 However, our ... book of matthew scripturesWebSubcellular location of FTH1. Localized to the microtubules. Analysis based on one antibody, CAB008623, using immunofluorescence in human cells ... Analysis based on … god\u0027s plans are better than ours scripture