Drug rediscovery protocol
WebUnique Protocol ID: M15DRU : Brief Title: The Drug Rediscovery Protocol (DRUP Trial) (DRUP) Official Title: A Dutch National Study on Behalf of the CPCT to Facilitate Patient Access to Commercially Available, Targeted Anti-cancer Drugs to Determine the Potential Efficacy in Treatment of Advanced Cancers With a Known Molecular Profile WebMar 26, 2024 · The Drug Rediscovery Protocol (DRUP trial): A Dutch National Study on behalf of the Center for Personalized Cancer Treatment (CPCT) to Facilitate Patient Access to Commercially Available, Targeted Anti-cancer Drugs to determine the Potential Efficacy in Treatment of Advanced Cancers with a Known Molecular Profile
Drug rediscovery protocol
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WebIn Drug Rediscovery Protocol (DRUP), patients with treatment-refractory solid malignancies receive offlabel drugs based on tumor molecular profiles while whole-genome sequencing (WGS) is performed on baseline tumor biopsies. The primary endpoint was clinical benefit (CB; defined as objective response or stable disease ≥ 16 weeks … WebMar 15, 2024 · The Drug Discovery Process involves many different stages and series of actions. Typically, it can be divided into four main stages: Early Drug Discovery, Pre …
WebJun 15, 2024 · Abstract. Large-scale genetic tumor profiling can identify increasing numbers of potentially actionable molecular variants for which approved anticancer drugs are … WebDiscovery. Typically, researchers discover new drugs through: New insights into a disease process that allow researchers to design a product to stop or reverse the effects of the …
WebThe Drug Rediscovery Protocol (DRUP trial) A Dutch national study on behalf of the Center for Personalized Cancer Treatment (CPCT) to improve patient access to commercially available, registered anti-cancer drugs that target specific cancer cell alterations, to determine the efficacy of these drugs when used for treatment of patients … WebMethod Article. The Drug Rediscovery Protocol (DRUP trial): A Dutch National Study on behalf of the Center for Personalized Cancer Treatment (CPCT) to Facilitate Patient Access to Commercially Available, Targeted Anti-cancer Drugs to determine the Potential Efficacy in Treatment of Advanced Cancers with a Known Molecular Profile
WebAll patients who receive treatment with a drug available in the protocol will be followed for standard efficacy outcomes including tumor response, progressionfree - and …
WebJul 1, 2016 · National Center for Biotechnology Information mark abell attorneyWebPatients and methods: In the Drug Rediscovery Protocol (DRUP), therapy refractory metastatic cancers patients, harboring an actionable molecular profile are matched to FDA/EMA approved targeted- or immunotherapy. Patients are enrolled in parallel cohorts based on the histological tumor type, molecular profile and study drug. ... darling pro solutionsWebD RUP -The Drug Rediscovery Protocol (DRUP trial) A Dutch National Study on behalf of the Center for Personalized Cancer Treatment (CPCT) to Facilitate Patient Access to … mark abruzzo attorneyWebMay 22, 2024 · In the Drug Rediscovery Protocol (DRUP) , a national ongoing pan-cancer multi-drug basket/umbrella trial, patients are treated off-label with registered drugs based on their tumor molecular profile. The innovative design allows for an infinite number of cohorts, testing multiple hypotheses in parallel. The DRUP facilitates access to potentially ... darling quote.comWebSep 8, 2024 · That is the basis for our Drug Rediscovery Protocol, which currently includes 19 different drugs from 10 pharmaceutical companies,” Voest reported. Since the trial was launched in late 2016, over 250 cases have been submitted for review: of these, about 70 patients have so far been found eligible and started treatment. mark accettura attorneyWebSep 30, 2024 · The Drug Rediscovery protocol facilitates the defined use of approved drugs beyond their labels in rare subgroups of cancer, identifies early signals of activity … mark abbott solicitorsWebJun 15, 2024 · Therefore, we initiated the Drug Rediscovery Protocol (DRUP), an innovative and adaptive precision oncology trial aimed at identifying signals of activity in … darling q significa